Fabrication of Ultra-fine Powder by Ultrasonic Spray Drying 

Spray drying is a systematic technology applied to material drying. After atomizing the solution or suspension of raw material, the moisture vaporizes rapidly in contact with hot air and dry products are achieved. This method can directly dry the solution and suspension into powder or granular products, eliminating evaporation, crushing and other processes, so it is also called spray granulation. Using ultrasonic atomization technology, the suspension can be uniformly atomized into micron or submicron aerosol droplets, and the atomized droplets can be sent to the high temperature chamber for drying by carrier gas. Ultrasonic spray drying can produce more uniform, smaller and powder particles with better morphology than traditional spray drying (centrifugal sprayer or air sprayer). It has great prospects in industries of nano materials, fine chemicals, biomedicine, etc. For example, inhalation administration is a typical administration for the treatment of upper respiratory tract diseases. Generally, the drug solution is atomized and inhaled by patients. For example, atomized particles of about 5 microns can deliver drugs to the lungs. If the drug is directly made into uniform particles of about 5 microns, there will be unnecessary to dissolve the drug into solution and then atomize inhalation. More directly drug contact will significantly improve the treatment effect. At present, Siansonic ultrasonic spray drying nozzle and ultrasonic aerosol generator have successfully completed the preparation of 5-micron dry powder inhalable drug in the laboratory. Ultrasonic spray drying with advantages of high production efficiency and great particle uniformity are expected to become an excellent solution for mass production of dry powder inhalable drug particles in the near future.

Siansonic has almost 40 years of experience in ultrasonic atomization technology, and can provide various ultrasonic spray drying solutions to customers from R&D to mass production. Siansonic patented ultrasonic spray drying nozzles and ultrasonic aerosol generators have the advantages of high temperature protection, self-cooling, fine and uniform atomized droplets, and can be easily and quickly connected to the existing spray drying equipment.